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Renin antibody staining of reproductive tissues of the rat estrus cycle
Author(s) -
Hurley Mary,
DenHaese Jason,
Heller Scott,
Tyrpak Stephen,
Bansal Roli,
Manu Pauline,
Mosher Nicole,
Alden Ashley,
Jones Craig Pace,
Olivieri Marion Pace
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.689.12
Subject(s) - renin–angiotensin system , endocrinology , medicine , biology , trophoblast , uterine artery , estrous cycle , human chorionic gonadotropin , placenta , hormone , andrology , fetus , blood pressure , pregnancy , gestation , genetics
Renin is an important kidney vasculature‐produced hormone that is released with a drop in the vascular flow rate through the glomerulus. It activates angiotensinogen, which is altered to angiotensin I, and altered again in lung tissue to angiotensin II, causing a release of aldosterone from the adrenal cortex and an increase in blood pressure, thereby increasing the vascular flow rate through the glomerulus. Renin is also a hox gene product in the mouse, in the abdominal region, found in fetal paired vessels of the abdominal aorta, supplying adrenal glands, kidneys, and gonads. After birth renin is still present in mouse ovarian/uterine artery, but not in the testicular artery. It is also present in giant trophoblast cells of the mouse placenta. Our lab has shown that renin is produced in rat female reproductive tissues, in the ovarian/uterine arteries and giant trophoblast cells, using anti‐mouse renin antibodies. This study examines the sites of renin immunohistochemical staining in rat female reproductive tissues during each stage of the estrus cycle. Anti‐mouse renin antibody generously donated by Dr. Kenneth Gross of RPCI. Research supported by DYC faculty research committee funding.