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Increase in renal sympathetic nerve activity and hypertension in rats with chronic femoral artery occlusion
Author(s) -
Yang Hsiao Tung,
King Louise T,
Terjung Ronald L,
Hasser Eileen M
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.689.1
Subject(s) - medicine , stimulation , blood pressure , heart rate , sciatic nerve , cardiology , sympathetic nervous system , mean arterial pressure , femoral artery , femoral nerve , peripheral , anesthesia , endocrinology
Patients with peripheral arterial insufficiency (PAI) show augmented sympathoexcitation (SE) (higher blood pressure (BP) and heart rate (HR)) during graded physical activity. Chronically elevated SE is detrimental in cardiovascular control and may contribute to the higher morbidity and mortality in PAI patients. In rats with femoral artery occlusion (FemOccl), a model of PAI, BP is elevated at both rest or during exercise. We hypothesized that the increased afferent activity from the hind limbs contributes to the increased BP and possibly via an altered sympathetic nerve activity (SNA) in FemOccl rats. 24 adult male SD rats received FemOccl for 3 to 5 wks. Arterial BP, heart rate and renal SNA responses to sciatic nerve afferent stimulation were monitored. Under Inactin anesthesia, baseline BP was 119±1.6 in Control (n=12) and 130±4.4 mmHg (n=11, p<0.025) in FemOccl rats. Baseline renal SNA was also about 38% higher in FemOccl rats (p<0.05). Stimulation (100 – 600 uA, 1 ms, 15 Hz) of the central end of the cut right sciatic nerve produced significantly greater increases in renal SNA in the FemOccl group compared to Control (p<0.05). Our preliminary observations imply that the central nerve system (CNS) control circuit remodels to enhance SE, and contribute to the hypertension after FemOccl. This raises the potential that an altered CNS control could contribute to a chronic SE state.