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Functional capillary recruitment during cephalic phase of digestion is blunted in obesity
Author(s) -
Buss Caroline,
KraemerAguiar Luiz Guilherme,
Maranhão Priscila Alves,
Bouskela Eliete
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.687.13
Subject(s) - saliva , medicine , context (archaeology) , basal (medicine) , digestion (alchemy) , endocrinology , biology , chemistry , paleontology , chromatography , insulin
Context In healthy subjects, functional capillary recruitment (FCR) occurs during the cephalic phase of digestion (CPD), suggesting a precocious role for the microcirculation in the physiology of digestion and nutrient homeostasis. Objective To investigate if such response is present in obese subjects. Methods Twenty‐nine obese subjects, 28.6±2.8 years (mean±SD) and BMI of 36.7±2.2 kg/m 2, were randomized into receiving cognitive‐sensorial stimuli of a breakfast tray to elicit CPD (CPD group, n=15) or not (control group, n=14), after a 12‐h overnight fast. Main outcomes were differences in resting and peak functional capillary density (FCD, cap/mm 2 ) evaluated by videocapillaroscopy. Saliva assessment was used as a clinical marker of successful CPD stimulation. Results No significant difference was detected on basal (53.6±12.8 to 52.3±8.9, p = 0.621 ) and peak FCD (58.5±10.6 to 55.7±9.4, p = 0.239 ) in the CPD or in the control group. Saliva secretion significantly increased in the CPD (9.3±8.5 to 13.4±8.4 mm, p =0.015) and remained unchanged in the control group. Conclusions FCR during CPD is blunted in obesity and the increment in saliva secretion indicates responsiveness to the sensorial stimuli. Mechanisms involved in this response should be further investigated. Research Support: Coordination for the Enhancement of Education Personnel (CAPES); State of Rio de Janeiro Carlos Chagas Filho Research Foundation (FAPERJ)