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High Dietary Fat Intake Does Not Influence Endothelial Fibrinolytic Function in Older Adults
Author(s) -
Greiner Jared,
Stauffer Brian,
DeSouza Christopher
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.686.8
Subject(s) - calorie , medicine , endocrinology , bradykinin , sodium nitroprusside , endothelium , plasminogen activator , nitric oxide , receptor
High dietary fat intake is linked to an increased risk of cardiovascular disease. Diminished fibrinolytic capacity underlies thrombogenic risk. The capacity of the endothelium to release tissue‐type plasminogen activator (t‐PA) is critical to endogenous thrombolysis. We have previously demonstrated that endothelial t‐PA release is impaired with aging. It is currently unknown if a high fat diet further worsens t‐PA release in older adults. The aim of this study was to determine the influence of dietary fat intake on t‐PA release in older adults. 26 older healthy adults were studied: 14 consumed a lower fat diet (age: 61±1 yr; % of calories from fat: 30±1; LFD) and 12 consumed a higher fat diet (59±1 yr; % of calories from fat: 42±2; HFD). Dietary fat content was assessed by 4‐day dietary recall. Net endothelial release of t‐PA was determined, in vivo, in response to intrabrachial infusions of bradykinin (BK: 125–500 ng/min) and sodium nitroprusside (SNP: 2.0–8.0 μg/min). Total caloric intake was similar between the groups (LFD: 2111±153; HFD: 2514±172 kcals). Net t‐PA release and total t‐PA release to BK were not significantly different between the LFD (from −0.2±0.5 to 44.7±5.3 ng/100 mL tissue/min; 239.9±27.6 ng/100 mL tissue) and HFD (from −0.6±0.6 to 42.8±5.9; 234.8±29.0) groups. High dietary fat intake does not worsen the capacity of the endothelium to release t‐PA in older adults.