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Recording of intracranial pressure in conscious rats via telemetry
Author(s) -
Guild SarahJane,
McCormick Daniel,
Lim Matthew,
Pauly Bob,
Kirton Robert,
Budgett David,
Kondo Masahiro,
Stehlin Ellyce,
Barrett Carolyn J,
Malpas Simon C
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.683.4
Subject(s) - telemetry , intracranial pressure , biomedical engineering , hydrocephalus , pressure sensor , catheter , medicine , intracranial pressure monitoring , brain tissue , skull , anesthesia , surgery , computer science , telecommunications , physics , thermodynamics
Measurement of intracranial pressure (ICP) is a critical diagnostic measure in treating head trauma, intracerebral hemorrhage and hydrocephalus. The pressure values are generally between 5–15 mmHg with >;20 mmHg considered abnormal. There is a scarcity of animal models of chronic ICP measurement in part associated with the difficulty of measuring ICP chronically with good accuracy. Previous telemetry devices utilizing fluid filled catheters have proved problematic due to movement artefacts. We implanted TRM54P telemetry devices which incorporate a solid state 2 Fr (0.6 mm) sensor in rats. The pressure sensor catheter was tunnelled subcutaneously to the skull and inserted thru the dura to lie against the brain tissue. We also performed drift assessments on the sensors over time before and after implantation and using bench measurements.