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Effects of propofol and midazolam on picrotoxin ( PTX)‐ induced convulsions in the rat.
Author(s) -
Hasan Zuheir A
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.662.10
Subject(s) - propofol , midazolam , anesthesia , medicine , status epilepticus , anticonvulsant , convulsant , convulsion , anesthetic , epilepsy , saline , benzodiazepine , sedation , receptor , psychiatry
Propofol , a short‐acting , intravenous anesthetic, has been used in the treatment of status epilepticus. However, reports of seizure‐like movements during either induction or recovery from propofol anesthesia promoted concerns that propofol may have proconvulsant effects in some patients. Our prior studies showed that propofol displays anticonvulsant effects in several seizures models at peak anesthetic effect. This study examines the time course of the effects of intravenous (i.v) administration of various doses of propofol and midazolam on seizures induced by intraperitoneal (i.p) injection of the convulsant PTX. Male Sprague‐Dawley rats (250–300 gm) were treated with PTX (4 mg/kg). Five min following PTX treatment, and before the onset of seizures, groups of rats (N=10), were given propofol (5, 10 , 20 mg /kg) or midazolam (2.5, 5, 10 mg/kg) via a tail vein. Control rats had saline. Individual rats were placed in plexiglass cages and observed for two hours The latency to clonic seizures was recorded. Incidence of clonic and generalized tonic‐clonic seizures were recorded Mortality over 24 hours was also observed. The higher two doses of propofol and all doses of midazolam significantly increased the latency of clonic seizures. However, propofol did not significantly affect the incidence of generalized tonic‐clonic seizures. In contrast, the higher two doses of midazolam significantly reduced the incidence of generalized tonic‐clonic seizures and greatly reduced mortality. These findings suggest that midazolam was more effective than propofol in aborting PTX‐induced generalized tonic‐clonic seizure. Supported by a research grant from Arabian Gulf University.