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ageLOC Vitality improves memory and learning ability in memory impairment models
Author(s) -
Tan NingZhi,
Yang JieYing,
Yang Guang,
Zhu JiaShi
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.661.4
Subject(s) - morris water navigation task , memory impairment , medicine , psychology , cognition , neuroscience , hippocampus
Based on the differential gene expressions found in skeletal muscle and neocortex of Young (5‐mo) and Old (25‐mo) mice, ageLOC Vitality, containing Cordyceps sinensis Cs‐4 and extracts from ginseng and pomegranate, opposes the age‐associated changes in global gene expressions, and improves endurance exercise and sexual functions. We further examined its effect on memory functions at a dose of 200, 400 or 800mg/kg in mice by using both shuttle‐box and Morris water‐maze tests. Three models were used with impairment of memory acquisition (MAI, by scopolamine), memory consolidation (MCI, by sodium nitrite), and memory reproduction (MRI, by ethanol). In shuttle‐box avoidance test, Vitality shortened active avoidance latency (AAL) and increased active avoidance response rate (AARR) in (1) MAI: AAL −47 to −70% (p<0.001) and AARR +109 to +209% (p=0.007); (2) MCI: AAL +9.5 to −44% (p=0.024) and AARR +59 to +149% (p=0.002); and (3) MRI: AAL +10 to −52% (p=0.014) and AARR +17 to +203% (p<0.001). In water‐maze test, Vitality shortened the swim time to platform in MAI: −14 to −57% (p=0.008), and in MRI: −29 to −43% (p=0.019). Our results indicate ageLOC Vitality is effective in improving memory and learning ability in mice with memory impairments, supporting its potential anti‐aging effect.