Premium
Adolescent traumatic stress experience shapes adulthood fear conditioning and extinction responses
Author(s) -
Moore Nicole LT,
Gauchan Sangeeta,
Genovese Raymond F
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.661.11
Subject(s) - fear conditioning , extinction (optical mineralogy) , psychology , conditioning , freezing behavior , stimulus (psychology) , classical conditioning , developmental psychology , audiology , unconditioned stimulus , conditioned response , medicine , anxiety , psychiatry , cognitive psychology , paleontology , statistics , mathematics , biology
A traumatic stress paradigm (underwater trauma, UWT) was used to model an intense developmental stress event during adolescence, and evaluate effects on fear and stress response lasting into adulthood. Adolescent rats (P37) were exposed to UWT or swim without submersion. Rats were then allowed to reach adulthood (P114) and fear conditioned using light and sound (conditioned stimulus), with or without footshock (unconditioned stimulus). After a three‐week fear incubation period, rats were given one extinction trial per day for five consecutive days using an operant behavior conditioned suppression task. Preliminary results suggest that adolescent traumatic stress experience shapes some aspects of adulthood stress response severity, and residual fear responses after five extinction trials. This work is supported by the Military Operational Medicine Research Program, US Army Medical Research and Materiel Command.