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EXAMINING THE RELATIONSHIP BETWEEN COCAINE AND SLEEP IN A MONKEY MODEL OF DRUG ABUSE
Author(s) -
Brutcher Robert,
Nader Michael
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.659.2
Subject(s) - morning , self administration , sleep (system call) , medicine , psychology , anesthesia , circadian rhythm , physiology , computer science , operating system
Clinical literature suggests that sleep deprivation can induce patients to relapse to drug taking. This animal study examined the effects of cocaine (COC) self‐administration on several sleep measures and how sleep disruption affects COC preference. Subjects were 8 adult male rhesus monkeys (Macaca mulatta), each wearing Actical activity monitors on their collar and surgically implanted with an indwelling intravenous catheter for COC self‐administration. Baseline activity was monitored for 1 week in the absence of any behavioral testing. Each morning (0730), monkeys were permitted to respond under choice procedure in which food reinforcement (three, 1‐g banana‐flavored pellets) was contingent upon completing the response requirement on one lever, while COC (0.003–0.1 mg/kg/injection) or saline presentation was contingent on responding on the other lever. After baseline cocaine‐choice curves were determined, the monkeys were sleep disrupted. Our results indicate that COC self‐administration causes significant changes on several sleep measures, providing evidence for possible treatment strategies. We also found that sleep disruption caused significant changes on sleep measures but did not alter the reinforcing strength of COC the next morning. Future studies will examine a medication that may enhance sleep (quetiapine) and may also decrease COC self‐administration. DA025120