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Subjective and Cardiovascular Responses to Cocaine Differ in Cigarette Smokers versus Nonsmokers
Author(s) -
Brewer Alex Jawann,
Arnoudse Nicholas,
Mahoney James J,
Newton Thomas F,
De La Garza Richard
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.659.17
Subject(s) - heart rate , medicine , placebo , blood pressure , cigarette smoking , statistical significance , cocaine use , nicotine , physiology , psychiatry , alternative medicine , pathology
In this placebo‐controlled, between‐subjects study, we evaluated the cardiovascular and subjective responses to cocaine (40 mg, IV) administered in the laboratory in cigarette smokers versus non‐smokers. . Participants (N=8/group) were matched by gender, age, years of education, years of drug use, amount of daily drug use, and number of days used in the last month. At present, analyses of the data indicate that cigarette smokers exhibited greater changes in heart rate and blood pressure and several subjective effects than non‐smokers, though these did not reach statistical significance (all p's >;0.05). For example, changes in heart rate were greater at early time points (5 min), but also at later time points (60, 90, 120 min) suggesting sustained effects produced by cocaine in smokers as opposed to non‐smokers. A similar trend was observed for changes in “high”, “good effects”, and “stimulated”. Taken together, the available data support the hypothesis that smokers differ from non‐smokers in their cardiovascular and subjective responses to cocaine. Data acquisition and analyses are continuing.