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Effect of a new compounds of substituted 5R1, 6H2–1,3,4‐thiadiazine‐2‐amines on the histological pictures in ligation models of experimental acute myocardial infarction and experimental acute pancreatitis in rats.
Author(s) -
Sarapultsev Alexey Petrovich,
Chupakhin Oleg Nickolaevich,
Sarapultsev Petr Alekseevich,
Rantsev Maxim Anatolevich,
Medvedeva Svetlana Ur'evna,
Danilova Irina Georgievna
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.650.4
Subject(s) - inflammation , granulation tissue , ligation , acute pancreatitis , medicine , myocardial infarction , necrosis , pancreatitis , experimental animal , pathology , immunology , veterinary medicine , wound healing
Models of experimental acute myocardial infarction (EAMI) and experimental acute pancreatitis (EAP) have been developed to solve this problem. The animals got injection of the compound from the group of substituted 5R1, 6H2–1,3,4‐thiadiazine‐2‐amines, dozed 40 mg/kg. Histological study has been carried out at the 1st, 5st and 7th days. All animal experimental procedures were performed in accordance with the APS's Guiding Principles and in accordance with the Laboratory Practice Regulations of RF. Already during the 1st day of the EAMI no leucopenia was observed and the signs of proliferative inflammation were detected. Later, at the 5th day, the necrosis area got surrounded by demarcation bank, and further on (7th day) had been entirely replaced by granulation tissue. Withal, the application of compound in EAP results in occurrence of proliferative inflammation, prevents lympho‐ and monocytopenia development and cuts down the lethality rate two‐fold. Conduction research enabled to state repeatability of the mechanism of the compounds impact on ischemia‐induced inflammation process, both in case of EAMI and EAP. The compounds modulated the transition of destructive inflammation into proliferative one, thereby preventing spreading of the inflammation process to tissues surrounding the necrotic zone and promoting reparative processes as well. Research Grant 12‐Ì‐34–2064 of Ural Branch of RAS.