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Immuno‐stimulating Activities of Polysaccharides from Korean Red Ginseng in Cyclophsphamide‐treated Immunosuppressed Mice
Author(s) -
Cho ChangWon,
Han Chunji,
Hong HeeDo,
Rhee Young Kyoung,
Nam SoHyun,
Sung SuKyung,
Rho Jeonghae,
Choi Sang Yoon,
Lee YoungChul
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.643.7
Subject(s) - polysaccharide , ginseng , arabinose , galactose , chemistry , sugar , mole , biochemistry , xylose , medicine , alternative medicine , pathology , fermentation
In this work, the crude polysaccharide (RGW‐0) was isolated from Korean red ginseng by hot water extraction, ethanol precipitation and dialysis. The major constituents in RGW‐0 were neutral sugar (73.5%), acidic polysaccharide (26.3%). The neutral sugar was composed mainly of glucose (75.6 mole%), arabinose (9.9 mole%), and galactose (7.4 mole%). We also investigated the immuno‐stimulating activities of RGW‐0 in 30 male Chinese Kun Ming mice immunosuppressed by treatment with cyclophophamide. The mice were divided into three groups, and treated by oral administration with RGW‐0 into two dosages (100 mg/kg and 200 mg/kg body weight) for 4 weeks. The results showed that RGW‐0 stimulated proliferation of splenic lymphocytes (T and B cells) in cyclophophamide‐induced immunosuppressed mice. RGW‐0 also markedly increased the natural killer‐cell activity and peripheral white blood cell number. This result showed that RGW‐0 could restore declined immune functions in immunosupressed mice and can be used as an effective immuno‐stimulator.