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Circulating pro‐inflammatory cytokines are elevated and peak power output correlates with 25‐hydroxyvitamin D in vitamin D insufficient adults
Author(s) -
Barker Tyler,
Dixon Brian M.,
Schneider Erik D.,
Weaver Lindell K.
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.643.2
Subject(s) - vitamin d and neurology , medicine , endocrinology , cytokine , vitamin d deficiency , vitamin , tumor necrosis factor alpha , isometric exercise , proinflammatory cytokine , chemistry , inflammation
The purpose of this study was to measure circulating cytokines, skeletal muscle strength, and peak power output in young adults with contrasting serum 25‐hydroxyvitamin D (25(OH)D) concentrations. Serum 25(OH)D, inflammatory cytokines, muscle strength, and peak power output were, therefore, measured in young adults (25 to 42 y). Data was collected during the winter to avoid the seasonal influence on serum 25(OH)D. After serum 25(OH)D concentration measurements, subjects were separated into one of two groups: (1) vitamin D insufficient (serum 25(OH)D ≤ 32 ng/mL, n = 14), or (2) vitamin D sufficient (serum 25(OH)D >; 32 ng/mL, n = 14). Following group allocation, serum 25(OH)D concentrations were significantly (p < 0.05) lower and pro‐inflammatory cytokines (interleukin (IL)‐2, IL‐1β, tumor necrosis factor (TNF)‐α, and interferon (IFN)‐γ) were significantly (all p < 0.05) greater in vitamin D insufficient adults. An anti‐inflammatory cytokine (IL‐10; p >; 0.05), peak isometric forces (p >; 0.05), and peak power outputs (p >; 0.05) were not significantly different between vitamin D groups. However, peak power outputs correlated with serum 25(OH)D concentrations in vitamin D insufficient (r = 0.55, p < 0.05) but not in vitamin D sufficient adults (r = −0.27, p = 0.36). We conclude that vitamin D insufficiency could result in pro‐inflammatory stress without altering muscular strength or function in young adults.