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The effect of calorie restriction with and without curcumin supplementation on inflammatory and T cell‐mediated immune responses of obese mice
Author(s) -
Wang Junpeng,
Vanegas Sally M,
Du Xiaogang,
Noble Timothy,
Zingg JeanMarc A,
Meydani Mohsen,
Meydani Simin Nikbin,
Wu Dayong
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.643.19
Subject(s) - immune system , inflammation , curcumin , endocrinology , medicine , t cell , diet induced obese , interleukin 10 , chemistry , immunology , pharmacology , obesity , insulin resistance
Obesity is associated with low‐grade inflammation and impaired T cell‐mediated immune response. Caloric restriction (CR) is shown to reduce inflammatory response and enhance cell‐mediated immune function. Spice compound curcumin (C) is proposed to have anti‐obesity and anti‐inflammation properties while piperine (P) enhances its bioavailability and efficacy. We determined if C/P could potentiate CR's beneficial effect on immune and inflammatory responses in diet‐induced obesity. Mice were fed a high‐fat diet (HFD) for 22‐wk followed by a CR diet (10% for 5‐wk and then 20% for additional 33‐wk), in the presence or absence of C and/or P. Results showed that compared to HFD control, all CR mice, with or without C and/or P, had fewer total spleen cells but a higher percentage of CD4 + T cells. CR resulted in a lower production of pro‐inflammatory cytokines IL‐1β and TNFα, and prostaglandin E 2 , as well as a trend toward lower IL‐6. Mice with CR alone had higher T cell proliferation and IL‐2 production, but this effect of CR was blunted by C and/or P. CR alone or in combination with C and/or P had no effect on production of cytokines IL‐4, IL‐10, IFN‐γ, TGF‐β, and IL‐17, or the proportion of different CD4 + T cell subsets. In conclusion, CR reduces inflammatory response and enhances T cell‐mediated function in HFD fed mice, but the presence of C and/or P does not provide additional benefit. Supported by the USDA contract #58–1950‐0–014.