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Development of respiratory tract infection could be modified by the interactions between maternal diet during pregnancy and offspring's CD14 (rs#2569190) and VDR (rs#7975232) polymorphisms
Author(s) -
Hong Seo Ah,
Kwon Sung Ok,
Kim Kyung Won,
Shin Youn Ho,
Ahn Kang Mo,
Yu Jinho,
Kwon JaYoung,
Choi SukJoo,
Lee KyungJu,
Won HyeSung,
Oh Seyoung,
Hong SooJong
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.640.23
Subject(s) - pregnancy , offspring , calcitriol receptor , medicine , genotype , cohort , physiology , asthma , vitamin d and neurology , immunology , biology , genetics , gene
Maternal diet during pregnancy can potentially influence disease susceptibility of offspring in addition to maternal atopy and genetic background. The objective was to investigate the association of prenatal antioxidant intakes and the genotype with the risk of respiratory tract infection (RTI) in 12‐month‐old infants. As part of a birth cohort study, the COhort for Childhood Origin of Asthma and Allergic Diseases (COCOA) (n=528), we assessed maternal diet during pregnancy by FFQ and genotyping of 4 genes (CD14, VDR, NRF2 and GSTP1) by the Taqman method. Maternal intakes of vit A and C, Fe, folic acid, and vegetable were negatively associated with the risk of RTI, particularly in the infants with atopic mothers (p<0.05). In combined analyses with genotype, we found significant interactions between the genetic variation in CD14 and vit A and C and fruit and between the genetic variation in VDR and fruit and vegetable regarding RTI (p<0.05). These findings suggest that the role of prenatal intakes of antioxidant nutrients related to lower risk of RTI may be modified by CD14 and VDR polymorphisms in infants. This study was supported by a fund (2008‐E33030–00, 2009‐ E33033–00, 2011‐E33021–00) from the Research of Korea Centers for Disease Control and Prevention. Grant Funding Source : Nutrition (ASN)