Premium
Effects of acute Pils‐beer consumption on alcohol‐induced liver steatosis in a mouse model
Author(s) -
Landmann Marianne,
Kanuri Giridhar,
Bergheim Ina
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.640.11
Subject(s) - steatosis , ethanol , ingestion , alcohol , lipogenesis , medicine , endocrinology , chemistry , alcoholic liver disease , apolipoprotein b , liquid diet , liver injury , fatty liver , cholesterol , biochemistry , lipid metabolism , cirrhosis , disease
Chronic alcohol abuse is still among the leading causes of liver‐related diseases worldwide. Studies suggest that not only the amount but also the type of alcoholic beverage may be critical in the development of alcoholic liver diseases. In the present study, the acute effects of Pils‐beer and plain ethanol intake on the liver were determined. C57Bl/6J mice either received a bolus ethanol, beer (6 g/kg BW, isocaloric) or maltodextrin solution. Fat accumulation, markers of lipogenesis and mRNA expression of MyD88 as well as concentration of 4‐hydroxynoneal protein adducts (4‐HNE), protein levels of the inducible NO synthase (iNOS) and ApoB were analyzed in livers 6h after the acute alcohol exposure. Despite similarly elevated plasma alcohol levels in both alcohol exposed groups, acute ethanol exposure caused a ~5‐fold increase (p<0.05) in hepatic lipid accumulation while the ingestion of beer only lead to a ~2‐fold increase (n.s.) in comparison to controls. The less harmful effects of the beer were associated with a protection against an elevation of MyD88, SREBP‐1c and FAS mRNA expression as well as the increase of iNOS protein levels and 4‐HNE protein adducts in the liver. Protein levels of hepatic ApoB were significantly induced of Pils‐beer but not ethanol‐treated mice. Taken together, these data suggest that the acute ingestion of Pils‐beer may be less harmful on the liver than ethanol in mice.