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ALOX5 gene variations modulate plasma triglyceride levels during an n‐3 polyunsaturated fatty acid supplementation
Author(s) -
Cormier Hubert,
Rudkowska Iwona,
Julien Pierre,
Couture Patrick,
Lemieux Simone,
Vohl MarieClaude
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.640.1
Subject(s) - single nucleotide polymorphism , polyunsaturated fatty acid , triglyceride , snp , endocrinology , medicine , fish oil , chemistry , polymorphism (computer science) , genotype , biology , gene , fatty acid , biochemistry , cholesterol , fish <actinopterygii> , fishery
Single nucleotide polymorphisms (SNPs) in the arachidonate 5‐lipoxygenase ( ALOX5 ) gene may play a role in lowering plasma triglyceride (TG) levels following supplementation with omega‐3 (n‐3) polyunsaturated fatty acids (PUFA). Objective To examine the effects of n‐3 PUFA supplementation on plasma TG levels in relation to the presence of SNPs in the ALOX5 gene. Methods 208 subjects completed a 2‐wk run‐in period followed by a 6‐wk supplementation with 5g/d of fish oil (1.9g of EPA + 1.1g of DHA). Genotyping of 12 SNPs of the ALOX5 gene was performed covering 86% of common genetic variations (minor allele frequency ≥0.05). Results Gene*diet interaction effects were observed for plasma TG (rs1565096 and rs7913948). Significant differences in TG levels were observed for SNP rs1565096 where AA homozygotes (HMZ) showed a smaller reduction of plasma TG levels as compared to GG HMZ (p=0.04). Conclusion Results suggest that SNPs in the ALOX5 gene may modulate plasma TG levels in response to n‐3 PUFA supplementation. Funding : FAST‐NSERC