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Individual genetic variations (IGV) of β,β‐carotene monooxygenase‐1 (BCMO1) are associated with changes in total cholesterol in young Mexican adults
Author(s) -
Marques Courtney,
TeranGarcia Margarita,
Erdman John W.,
VargasMorales Juan Manuel,
AradillasGarcia Celia,
Group UPAMIGOS
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.638.15
Subject(s) - cohort , genotype , population , medicine , obesity , cholesterol , endocrinology , biology , genetics , environmental health , gene
Retinoids are key in facilitating many physiological functions, including lipid metabolism, and are typically formed from the cleavage of β,β‐carotene by BCMO1. Recently, an IGV in the BCMO1 gene (SNP, rs10048138) was associated with cholesterol levels in a U. S. cohort; however, there are no replicates in the Mexican population. Our objective was to examine the association of this BCMO1 marker with cholesterol levels, a risk factor for metabolic disease, in college‐age individuals from the UP‐AMIGOS cohort. UP‐AMIGOS is a multidisciplinary project on genetics, obesity, and social environment between the U niversities of San Luis P otosi (San Luis Potosi, Mexico) and Illinois. For this cross‐sectional study genotype, health and nutrition data from 72 participants (aged 18–21 years) was analyzed. Homozygotes for the minor allele of BCMO1‐rs10048138 had lower cholesterol (137.4±9.8 mg/dL) compared to the other genotypes (158.1±2.7 and 157.6±4.0 mg/dL) adjusted for sex and age (p<0.04). Our analyses show that genetic variability in BCMO1 was associated with cholesterol levels and may prove to influence risk for metabolic disease; this association was strengthened (p<0.02) when considering smoking. Grant Funding Source : USDA/NIFA Hatch Project (#600108–793000‐793323 and #600109–698000‐698354)