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Gene expression of hepatic cortisol binding globulin and enzymes modifying sex hormones are modulated in mice by feeding the nonfermentable viscous soluble dietary fiber, HPMC
Author(s) -
Kim Hyunsook,
Bartley Glenn E,
Yokoyama Wallace
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.637.6
Subject(s) - medicine , endocrinology , hormone , gene expression , leptin , adipose tissue , biology , chemistry , obesity , gene , biochemistry
Global changes in hepatic gene expression in mice fed high fat diets and the nonfermentable viscous soluble dietary fiber, hydroxypropyl methylcellulose (HPMC) were determined by exon microarray. Obese C57BL/6J mice were fed either 6 % HPMC or 6 % microcrystalline cellulose (MCC) for five weeks. In addition to lowered plasma and liver lipids, body weight gain and adipose tissue weight were significantly lower in HPMC fed mice compared with MCC. We found that gene expression of CBG, the serpina6 gene, is decreased and that other sex hormone related genes were modulated by HPMC feeding. HPMC feeding also upregulated expression of genes related to PUFAs elongation. Cortisol, a steroid hormone, is regulated by the hypothalamic‐pituitary‐ adrenal (HPA). HPA affects obesity‐related chronic stress, which is also regulated differentially by sex hormones (such as androgens). Enzymes related to polyunsaturated fatty acid (PUFA) elongation have been shown to protect age‐related cognitive decline (ARCD). Therefore, in addition to already recognized positive effects on cholesterol and lipid metabolism HPMC intake may also affect neural functions such as gender‐related stress response and ARCD.