Premium
Vitamin D and calcium supplementation decrease body and fat weight gain and improve biomarkers of adiposity in diet‐induced obesity
Author(s) -
Song Qingming,
Sergeev Igor N
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.635.9
Subject(s) - endocrinology , medicine , vitamin d and neurology , calcium , vitamin , adipose tissue , obesity , weight gain , insulin , chemistry , body weight
Low vitamin D status (circulating concentration of 25(OH)D) and low calcium intake have been linked with an increased risk of obesity, however the underlying molecular mechanisms of vitamin D and calcium in obesity are not understood. To investigate effects of calcium and vitamin D supplementation on the development of obesity, male C57BL/6J mice (4 weeks of age) were fed for 10 weeks either a high fat (HF) diet (60% energy from fat) or HF diets containing 1.2% calcium, 10000 IU/kg vitamin D 3 and their combination. The results obtained demonstrated that the calcium plus vitamin D 3 supplementation reduced the body and adipose tissue (epididymal and retroperitoneal fat depots) weight gain and decreased the plasma glucose and insulin concentrations, as compared with the HF diet group. In addition, a high vitamin D 3 intake significantly raised the plasma concentrations of 25(OH)D and its hormonal form, 1,25(OH) 2 D, in HF diet‐fed mice. These findings indicate that increased dietary vitamin D and calcium intakes improve biomarkers of adiposity, insulin sensitivity, and vitamin D status in diet‐induced obesity and suggest a role for vitamin D and calcium in preventing body and fat weight gain. Supported by USDA 2009–35200‐05008 and USDA SD00H325 to INS.