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Potential roles for vitamins E and C in combination in modulation against exhaustive swimming‐and high altitude‐associated lung injury in rats
Author(s) -
ALHashem Fahaid,
Alkhateeb Mahmoud
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.632.2
Subject(s) - tbars , superoxide dismutase , effects of high altitude on humans , thiobarbituric acid , catalase , altitude (triangle) , glutathione , vitamin e , antioxidant , medicine , lung , endocrinology , chemistry , zoology , biology , lipid peroxidation , biochemistry , anatomy , enzyme , geometry , mathematics
The aim is to evaluate and compare the potential role of vitamins E and C in protecting against acute swimming induced lung damage at different altitudes. Rats at both altitude were divided into nonstress control group, forced swimming stressed group and vitamin E and C pretreated stressed group. At the end of the procedure, lung tissue level of thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) were determined. In control rats, the baseline levels of TBARS were significantly increased and the baseline levels of both GSH and SOD were significantly decreased in the lungs of animals at high altitude than those at low altitude. Acute forced swimming resulted a significant increase in TBARS levels and a significant decrease in activities of SOD and CAT in the lungs in both altitude areas, and resulted in a significant decrease in GSH levels at high altitude rats only as compared with the resting state. Supplementation of vitamins E and C in combination effectively ameliorated all the parameters measured at both altitudes. Our novel observations suggest that supplementation of vitamins E and C could be beneficial against exhaustive swimming‐and high altitude‐associated lung injury.