Premium
Is Exposure to Bisphenol‐A and Phthalates Associated with Obesity, Metabolic Disturbances and Insulin Resistance among U.S. adults?
Author(s) -
Beydoun Hind,
Khanal Suraj,
Zonderman Alan B,
Beydoun May
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.630.24
Subject(s) - insulin resistance , medicine , national health and nutrition examination survey , body mass index , obesity , endocrinology , phthalate , quartile , confounding , environmental health , confidence interval , chemistry , population , organic chemistry
Emerging evidence suggests that exposure to endocrine disruptors may initiate or exacerbate adiposity and associated health problems. This study examined the associations of urinary levels of bisphenol‐A (BPA) and phthalates with several adiposity‐related conditions among U.S. adults, namely, obesity, insulin resistance and metabolic disturbances. Secondary data analyses were performed using a sample of 3,566 participants from the 2005–2008 National Health and Nutrition Examination Surveys. Levels of BPA and 15 phthalate metabolites were defined in quartiles. Multivariate linear and logistic regression models for the hypothesized relationships were constructed after controlling for age, sex, race, education, marital status, smoking status, physical activity, total dietary intake and urinary creatinine level. BPA was positively associated with body mass index and negatively associated with high density lipoprotein cholesterol and diastolic blood pressure. Moreover, a positive relationship was observed for BPA level with triglycerides ≥ 150 mg/dL and insulin resistance. By contrast, total phthalates were not associated with the outcomes of interest after controlling for confounders. Prospective cohort studies are needed to examine BPA and phthalates as determinants of obesity, insulin resistance and other adiposity‐related conditions. Grant Funding Source : None