Premium
Hypolipidemic effect of Saururus chinensis Baill in ob/ob mice
Author(s) -
Choi HaNeul,
Kim JungIn
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.630.22
Subject(s) - triglyceride , hyperlipidemia , schisandra chinensis , cholesterol , christian ministry , traditional medicine , medicine , diabetes mellitus , total cholesterol , endocrinology , traditional chinese medicine , philosophy , alternative medicine , theology , pathology
Tight control of hyperlipidemia is associated with the reduced risk for cardiovascular diseases in diabetic patients. The purpose of this study was to investigate the hypolipidemic effect of S. chinensis Baill in obese diabetic ob/ob mice. Four‐week‐old male ob/ob mice were fed AIN‐93G diet or diet containing a 0.3% ethanol extract of S. chinensis Baill for 10 weeks after 1 week of adaptation. Animals were sacrificed after an overnight fast. Serum triglyceride, total cholesterol, and HDL‐cholesterol levels were measured. Consumption of S. chinensis Baill significantly decreased serum triglyceride and total cholesterol levels compared with the control group (p<0.05). Serum HDL‐cholesterol levels of the S. chinensis Baill group were not significantly different from those of the control group. Non‐HDL‐cholesterol levels of the S. chinensis Baill group were significantly lower than those of the control group. These results indicate that S. chinensis Baill is effective in improving hyperlipidemia in ob/ob mice and could contribute to reducing cardiovascular complications. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2009–0090780).