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The changes of chemerin and chemerin receptor to regulate lipid metabolism in liver and pituitary gland
Author(s) -
Roh Sanggun,
Kitayama Shun,
Ardiyanti Astrid,
Suzuki Yutaka,
Yamauchi Eri,
Kato Daiki,
Yi Kwonjung,
So Kyoungha,
Hagino Akihiko,
Katoh Kazuo
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.630.20
Subject(s) - chemerin , endocrinology , medicine , adipokine , adipose tissue , lipid metabolism , biology , insulin resistance , insulin
Chemerin was identified as a novel adipokine highly expressed in adipose tissue, suggesting that it plays a role in the pathophysiology of obesity. Chemerin actions are primarily mediated through binding to receptor expressed in several tissues. Likewise, chemerin expression has been detected in a variety of extra adipose tissues, including liver and pituitary. However, the expression and regulation of chemerin and its receptor mRNA in the liver and pituitary as a link in the lipid metabolism were not cleared. Chemerin function at the liver and pituitary was assessed by analyzing the expressions of both chemerin and chemerin receptor gene. The levels of chemerin and chemerin receptor mRNA was not changed in the liver in mice fed high fat diet compared with normal diet. However, these genes were upregulated in the adipose tissue in mice fed high fat diet. Chemerin mRNA expression was down‐regulated in pituitary gland in mice fed high fat diet, however chemerin receptor was not changed. Chemerin gene expression was up‐regulated in pituitary during 12 h of fasting, while chemerin receptor was not affected. Insulin and glucose treatment for 6h in HepG2 cells increased chemerin gene expression. These results suggest that that chemerin, either locally produced from the liver and pituitary, may play an endocrine role in the control of lipid metabolism via its own receptor.