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Dietary‐resistant starch improves glycemic control in STZ‐induced diabetic rat
Author(s) -
Huang Hui Yu,
Chao HuanChun,
Kao YuYu,
Tsao ShuPing,
Sie ChangHong,
Chen WenChi
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.630.2
Subject(s) - postprandial , glycemic , resistant starch , medicine , endocrinology , diabetes mellitus , starch , glycemic index , insulin resistance , digestion (alchemy) , fructose , insulin , meal , chemistry , food science , chromatography
Dietary resistant starch (RS) is dietary carbohydrates that resist digestion in the small intestine and reach the large intestine. In the current study, we hypothesize that supplement dietary resistant starch with meal can improve glycemic control in diabetic rat. The RS was added into diary high fat diet, and used STZ to induced hyperglycemia with the Sprague Dawley (SD) rats for 10 weeks. The High fat diet and the RS diet contained 7 % ( weight/weight) resistant starch. SD rats (n=40) were divided into four groups, and served as control, high fat‐fructose group (HFD), HFD+RS group. The body weight, food intake were monitored weekly. The blood glucose, OGTT, insulin level, and HbA1C were measured during or after treatment period. The result showed that RS reduction of postprandial and fasting blood glucose level, HbA1C and AUC. Also RS improved insulin sensitivity in the HFD+RS group as indicated by HOMA‐IR. In clusion, RS is beneficial to overcome from the high fat diet/STZ induced diabetic complicated.