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Hypoglycemic effect of Hedyotis diffusa in ob/ob mice
Author(s) -
Kang MinJung,
Kim JungIn
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.630.10
Subject(s) - adiponectin , christian ministry , insulin resistance , medicine , glycemic , endocrinology , type 2 diabetes , insulin , diabetes mellitus , traditional medicine , philosophy , theology
Tight control of hyperglycemia is the main goal for the treatment of diabetes mellitus. The purpose of this study was to investigate the hypoglycemic effects of Hedyotis diffusa in an animal model of type 2 diabetes. Four‐week‐old ob/ob mice (n=14) were fed AIN‐93G diet or diet containing 1% ethanol extract of Hedyotis diffusa for 8 weeks after 1 week of adaptation. Serum glucose, insulin, and adiponectin levels were measured. Homeostasis model assessment‐insulin resistance (HOMA‐IR) was calculated by dividing the product of fasting insulin (μU/mL) and glucose (mmol/L) by 22.5. Consumption of Hedyotis diffusa significantly decreased serum glucose levels (p<0.05) and tended to decrease insulin levels compared with the control group. HOMA‐IR of Hedyotis diffusa group was significantly lower than the control group (p<0.05). Serum adiponectin levels of Hedyotis diffusa group were significantly higher than the control group (p<0.05). These results demonstrated that Hedyotis diffusa could improve glycemic control in an animal model of type 2 diabetes. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2010–0011980).