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Fortification of Donor Human Milk for Premature Infants
Author(s) -
Bissett Emily,
Fogleman April,
Cohen Ronald,
Sakamoto Pauline,
Allen Jonathan
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.629.17
Subject(s) - bioavailability , calcium , chemistry , digestion (alchemy) , phosphate , food science , pharmacology , medicine , biochemistry , chromatography , organic chemistry
Premature infants at risk for metabolic bone disease may need increased minerals for normal bone mineralization, in which case supplementation of donor human milk (DHM) with calcium (Ca), phosphorus (P), and post‐discharge formula (PDF) is common. The bioavailability of these additives has not been proven. Objectives were to study the effect of Ca, P, and PDF supplementation on the bioaccessibility of calcium and phosphate. A novel in‐vitro model of the premature infant's gastrointestinal tract was developed to simulate effects of digestion, absorption and transport. Calcium and phosphate were measured before and after in‐vitro digestion in DHM with and without added supplements. Bioaccessible calcium was greater in DHM with supplemental calcium and calcium and phosphate together than in DHM alone or with supplemental PDF (p < 0.0001). Bioaccessible phosphate was not significantly different between treatment groups. The addition of minerals rather than PDF provides the most bioaccessible calcium. Funded by San Jose Mothers’ Milk Bank