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Sweet‐baked products, but not whole or refined grains, are negatively associated with bone mineral density (BMD): the Framingham Offspring Cohort
Author(s) -
Mangano Kelsey McKee,
Sahni Shivani,
Casey Virginia,
Hannan Marian T
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.622.9
Subject(s) - medicine , bone mineral , overweight , osteoporosis , framingham heart study , femoral neck , framingham risk score , cohort , endocrinology , obesity , disease
Objective To determine whether whole grains (WG), refined grains (RG); sweet‐baked products (SW) affect BMD at femoral neck (FN), trochanter (TR) & lumbar spine (LS) in adults. To examine BMI as an effect modifier. Methods Multivariable regression assessed relations between WG, RG & SW (from FFQ 1995–98) with BMD in 1996–2001 among 2,657 Framingham Offspring participants, adjusting for covariates. Energy adjusted quartiles of WG, RG and SW were grouped as Q1 (low), Q2–Q3 and Q4 (high). Associations were stratified by BMI <25 or ≥ 25 kg/m 2 . Results Mean age 59y ± 9.5. Intakes of WG, RG, SW were 1.2 ± 1.2, 2.9 ± 1.7; 0.9 ± 1.1 servings/d. WG and RG were not linked with any BMD site (P range: 0.23–0.99). High SW intake was inversely related to FN‐BMD (P=0.03) & TR‐BMD (P=0.01) compared to Q1. In overweight group, high SW intake was inversely related to all BMD sites compared to Q1 (Table). Controlling for total fat or carbohydrate intakes (g/d) had no effect. No relation was seen in the normal weight group between BMD and WG, RG or SW. Conclusions SW intake was inversely related to hip and spine BMD in overweight adults, independent of total fat and carbohydrate. Funding Source : NHLBI Framingham Heart Study (N01‐HC‐25195), Framingham Osteoporosis Study (NIH R01 – AR041398 ) Grant Funding Source : NIH NIAMS