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Longitudinal associations of blood biomarkers of insulin and glucose metabolism and colorectal cancer risk in the Framingham Heart Study Offspring population (1971–2008)
Author(s) -
Parekh Niyati,
Lin Yong,
Vadiveloo Maya,
Hayes Richard,
LuYao Grace
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.622.2
Subject(s) - medicine , colorectal cancer , hazard ratio , endocrinology , hyperinsulinemia , framingham risk score , population , diabetes mellitus , insulin , framingham heart study , glycemic , offspring , cancer , oncology , confidence interval , insulin resistance , disease , pregnancy , biology , environmental health , genetics
Higher blood glucose is hypothesized to increase colorectal cancer risk. Longitudinal associations of hyperglycemia with incident colorectal cancer were investigated among the Framingham Heart Study Offsprings (n=4192; n events=136; 1971–2008). Fasting insulin and glucose were estimated from blood samples; demographic, smoking, activity and dietary information was obtained during interviews. Time‐dependant survival analyses were used to compute hazard ratios (HR) and 95% confidence interval (CI) for colorectal cancer incidence, using SASv9.2. After adjusting for age, sex, smoking, alcohol and physical activity, hyperglycemia (>;110 mg/dl) was associated with 2.2‐fold increase in risk of incident colorectal cancer (HR: 2.21; CI:1.5–3.2). Risk was approximately 2‐fold higher among persons with hyperinsulinemia (HR:2.1; CI:1.1–3.9) and poor long‐term glycemic control measured by hemoglobin A1c (HR:2.2; CI: 1.1–4.5) for tertile 3 vs. 1 in adjusted models. Additionally, persons with 5–10y, 10–20y, 20+ y of hyperglycemia had a significant 1.8‐, 2.5 and 3.5‐fold increased risk of colorectal cancer, respectively. In conclusion, disturbances in glucose metabolism appear to increase risk of colorectal cancer. These data suggest that risk increases with the duration of exposure to hyperglycemia.