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Nutritional factors and c‐peptide preservation in type 1 diabetes
Author(s) -
MayerDavis Elizabeth Jane,
Dabelea Dana,
Crandell Jamie L,
Crume Tessa,
D'Agostino Ralph B,
Dolan Lawrence,
King Irena B,
Lawrence Jean M,
Norris Jill M,
Pihoker Catherine,
The Natalie
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.622.1
Subject(s) - docosahexaenoic acid , medicine , eicosapentaenoic acid , type 1 diabetes , confounding , vitamin d and neurology , type 2 diabetes , endocrinology , leucine , diabetes mellitus , insulin , physiology , fatty acid , amino acid , polyunsaturated fatty acid , biochemistry , biology
Preservation of endogenous insulin production in youth with recent onset type 1 diabetes (T1D) is associated with better outcomes. We tested the novel hypothesis that selected nutritional factors are prospectively associated with fasting c‐peptide (FCP). Included were 656 youth with T1D (mean diagnosis age 9.8 yrs [SD 3.9], T1D duration 9.9 mo [SD 6.3] at baseline study visit) who had preserved beta‐cell function at the baseline visit (FCP >; 0.23 ng/ml) and who participated in a follow‐up (mean time to follow up, 24.3 mo [SD 8.2]). Nutritional exposures assessed at the baseline visit included infant feeding, plasma eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), vitamins D and E; and, from a food frequency questionnaire, intake of leucine and carbohydrate. Longitudinal multiple linear regression models adjusted for baseline FCP value, time, demographics, T1D duration at baseline and other disease‐related factors and potential confounders. Baseline EPA (p=0.02), EPA + DHA (p=0.03), and leucine (p=0.03) were each positively and significantly associated with follow‐up ln(FCP) while vitamin D was unexpectedly inversely associated with FCP (p=0.002). Among youth with T1D, increased intake of branched chain amino acids and long‐chain n‐3 fatty acids may support preservation of beta‐cell function. This represents a new direction for future research to improve prognosis for T1D.