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Higher Body Mass Index, Lean Body Mass and Fat Mass Obtained by Bioimpedance are Associated with Slower HIV Disease Progression in Asymptomatic HIV+ Adults
Author(s) -
Luisi Sonya,
Campa Adriana,
Martinez Sabrina Sales,
Makhema Joseph,
Bussmann Hermann,
Farahani Mansour,
Marlink Richard,
Baum Marianna K
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.619.6
Subject(s) - body mass index , lean body mass , asymptomatic , medicine , mass index , viral load , disease , young adult , human immunodeficiency virus (hiv) , physiology , immunology , body weight
Objective To examine the effects of Lean Body Mass (LBM), fat mass (FM) and Body Mass Index (BMI) on HIV disease progression in 878 asymptomatic ART naïve HIV+ adults in Botswana. Methods This study is a secondary analysis of data collected by the parent study, Nutrient Therapy in Botswana. The relationship of CD4 cell count, log 10 HIV viral load, BMI, LBM and FM (obtained by bioimpedance) were analyzed by ANOVA and Linear regressions. Results Participants with higher LBM, FM and BMI had higher CD4 cell count [β=1.60, p=0.046] [β=1.40, p=0.042] [β=2.51, p=0.045] and lower viral load [β=−0.013, p=0.001], [β=−0.010, p=0.010], [β=−0.019, p=0.003] respectively, controlling for age, gender and physical activity. Conclusion These findings suggest that maintaining higher LMB, FM and BMI in HIV‐infected adults may maintain immune function early in the disease. This evidence supports the use of physical activity and adequate caloric and protein intake as effective interventions in HIV+ adults in early stages of the HIV disease to prevent weight loss and maintain adequate lean body mass, fat mass and body mass index. Funded by NIDA