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Relationships between infant morbidity, iron deficiency and growth
Author(s) -
Radhakrishna KV,
Balakrish,
Nair K Madhavan,
FernandezRao S,
Ravinder P,
Hurley K M,
Tilton N,
Harding K,
Reinhart G,
Black M M
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.618.9
Subject(s) - wasting , underweight , medicine , anthropometry , iron deficiency , pediatrics , wasting syndrome , diarrhea , logistic regression , micronutrient , malnutrition , anemia , body mass index , overweight , pathology
Objective To examine how caregiver infant morbidity reports relate to biomarkers of inflammation, iron deficiency and infant growth. Methods Among 497 infants age 6–12 months, morbidity was collected by 15 day caregiver recall. Biomarkers for iron deficiency (ID; ferritin< 12) and inflammation (CRP: C ‐ reactive protein >; 10mg/L); and anthropometry (measured weight and length) were collected. Stunting (HAZ<−2), wasting (WHZ <−2), and underweight (WAZ<−2) were computed using WHO standards. Chi‐square and multivariate logistic regression, adjusting for maternal anthropometry and education, child age, and household assets, were conducted. Results Among infants, 20% were stunted, 10% were wasted, 19% were underweight, 28% were ID, and 56% had an elevated CRP. Maternal reports of infant fever (35%) was related to elevated CRP and ID (p< 0.05), cough (28%) and diarrhea (11%) were related to elevated CRP (p< 0.05). In multivariate logistic models, ID (OR: 2.33; CI: 1.15–4.73) and fever (OR: 2.69; CI: 1.31–5.49) were related to wasting, and elevated CRP was related to stunting (OR=1.96; CI: 1.18–3.25) Conclusion Findings suggest that caregiver reports of recent infant morbidity relate to biomarkers of inflammation and ID, and that all three relate to poor growth in infants Research Support; Mathile Institute & Micronutrient Initiative