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DASH‐style diet is effective in patients with treated hypertension and diastolic heart failure independent of change in body weight – a pilot study
Author(s) -
Seymour E Mitchell,
Wells Joanna,
HanMarkey Theresa,
Soni Tanu,
Burant Charles,
Hummel Scott L
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.615.7
Subject(s) - dash , dash diet , medicine , blood pressure , micronutrient , heart failure , excretion , diastole , population , cardiology , weight loss , physiology , calorie , endocrinology , obesity , pathology , environmental health , computer science , operating system
“Diastolic heart failure” (DHF) is the most common type of heart failure over age 65 and is frequently associated with hypertension. The “Dietary Approaches to Stop Hypertension” diet can reduce blood pressure, but its effects in patients with DHF are unknown. This project tested the sodium‐restricted DASH diet in patients with hypertensive DHF using three weeks of controlled‐feeding with effort to maintain body weight. The experimental diet achieved DASH guidelines for nutrient intake without a significant change in total calories. DASH increased six‐minute walk distance and K + excretion while it reduced Na + excretion, systolic and diastolic blood pressure, post‐walk test dyspnea, and urinary 8‐ isoprostane. Of over 200 metabolites tested, few were significantly altered; changes in macronutrient metabolism were unlikely associated with clinical findings. Instead, altered micronutrient intake and phytochemicals from fruits/vegetables may be instrumental. Three weeks of the sodium‐restricted DASH diet significantly reduced blood pressure and oxidative stress in subjects with hypertensive DHF. This pilot study revealed endpoints affected early in a DASH diet intervention in this population, independent of changes in body weight. Furthermore, the study provides a model for longer DASH interventions aimed to affect cardiac geometry and function. Supported by NIH UL1TR000433 and K23HL109176.