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Thoracic Cavity Fluid Accumulation: A Possible Novel Biomarker in Hemodialysis Patients
Author(s) -
Sussman Elizabeth J,
Johnston Carol S.,
Boren Kenneth,
Singh Bhupinder
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.615.24
Subject(s) - hemodialysis , biomarker , medicine , phosphorus , hyperphosphatemia , gastroenterology , chemistry , materials science , kidney disease , metallurgy , biochemistry
Research shows chronic hemodialysis (HD) patient's hydration state, measured by whole body bioimpedence spectroscopy, is an independent predictor of mortality. Hyperphosphatemia is also independently associated with mortality in HD patients. It has yet to be determined if fluid accumulation, specifically in the thoracic cavity, is correlated to other predictors of mortality, including phosphorus. In this cross‐sectional study, stable HD patient's (n=25, 61.5±3.2y) thoracic cavity fluid accumulation (TCFA) was measured using the ZOE fluid status monitor (normal range: 19–30 ohms, lower values indicate greater fluid accumulation) and correlated to other traditional nutrition markers, including phosphorus, interdialytic weight gain (IDWG), and HD vintage (months). Results showed TCFA and phosphorus negatively correlated (r=−.479, r 2 =0.23, p=0.021), while TCFA and IDWG, and TCFA and HD vintage trended toward significance (r=−.386, p=0.063 and r= .371, p=0.074, respectively). These results suggest as two independent predictors of mortality (phosphorus and IDWG) increase, a greater TCFA is seen. Alternatively, as HD vintage increases, TCFA decreases. Funding: Academy of Nutrition and Dietetics Foundation Grant Funding Source : Academy of Nutrition and Dietetics Foundation