Premium
Use of HOMA indexes for the identification of metabolic syndrome and insulin resistance among Cuban‐Americans
Author(s) -
Exebio Joel C,
Ajabshir Sahar,
Zarini Gustavo G,
Shaban Lemia,
Huffman Fatma G
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.615.12
Subject(s) - insulin resistance , metabolic syndrome , medicine , percentile , endocrinology , obesity , cut point , insulin , insulin sensitivity , diabetes mellitus , mathematics , statistics
Objective To determine cut off points for HOMA‐1 and HOMA‐2 to identify insulin resistance and metabolic syndrome. Methods Subjects without diabetes residing in South Florida were enrolled (n=168, age 37 to 83 years). The HOMA‐1 and HOMA‐2 90th percentile in the healthy group (n=89) was used as the cut‐off point for insulin resistance. A ROC curve was constructed to determine the cut‐off point for metabolic syndrome. Results HOMA indexes were significantly correlated with fasting plasma glucose, central obesity, triglycerides and HDL cholesterol (P < 0.01). The cut‐off points for insulin resistance for HOMA‐1 and HOMA‐2 were >; 4.27 and >; 2.4 and for metabolic syndrome were >; 2.98 (69% sensitivity and 70.7% specificity) and >; 1.55 (65.4% sensitivity and 63.3% specificity), respectively. Conclusion HOMA cut‐off points may be used as a screening tool to identify insulin resistance and metabolic syndrome among Cuban‐Americans living in South Florida.