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Methacrylate polymer nanoparticle loaded with ZnPc as a promising anticancer drug delivery system
Author(s) -
Barros Susan S,
Gomes Anderson J
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.575.9
Subject(s) - zeta potential , methacrylate , photosensitizer , nanoparticle , methacrylic acid , drug delivery , ethyl acrylate , polymer , chemistry , singlet oxygen , photodynamic therapy , methyl methacrylate , materials science , nuclear chemistry , nanotechnology , copolymer , photochemistry , organic chemistry , oxygen
This study aimed to investigate the effect of a established cancer drugs such as Zinc Phthalocyanine (ZnPc) and it encapsulation into a matrix of ethyl acrylate copolymer, methyl methacrylate and a low content of methacrylic acid ester with quaternary ammonium groups (EUDRAGIT® RL 100). ZnPc a well‐known photosensitizer used in photodynamic therapy (PDT), was selected in these experiments due to its high affinity for tumor targets and efficiency due to singlet oxygen photogeneration. These new drug delivery systems (ZnPc‐NP) was designed to protect the drugs from environmental, to promote a sustained drug delivery profile and also be tracked by the emission of fluorescence probe. Size and entrapment efficiency were evaluated at different preparation protocols. ZnPc‐NP showed an entrapment efficient of 17.6% (2.5g of polymer) using a emulsification–evaporation method. Size measurements were compared with the empty nanoparticles, which showed values of 273± 50 nm, nanoparticles loaded with ZnPc showed values of 146.0± 72 nm. Empty particles zeta potential presented +38.0 ZnPc‐NP. Parameters analyzed in this study demonstrate new promise drug delivery systems, supporting future in vitro tests. Supported by CNPq, CAPES, FAPDF, FINATEC and DPP‐UnB.