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Production and characterization of Polylactic acid (PLA) nanoparticles containing drugs applied in cancer therapy
Author(s) -
Conceição João Bosco F,
Gomes Anderson J
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.575.3
Subject(s) - zeta potential , nanoparticle , bioavailability , materials science , drug delivery , nanotechnology , chemical engineering , chemistry , nuclear chemistry , pharmacology , medicine , engineering
Polymeric nanoparticles can be considered systems with increased therapeutic performance, since they are able to low the toxicity and side‐effects, increase bioavailability and efficacy of different drug classes. The aim is developing PLA nanoparticles containing tamoxifen (TMX‐PLA NPs) as promise to application in cancer therapy. The TMX‐PLA nanoparticles were prepared by the method of emulsion and solvent evaporation, presenting nanometer diameter (345.5 ± 3.0 nm), suitable zeta potential of − 8.73 ± 0.43 mV and high entrapping efficiency of 85%. Some variables for TMX‐PLA nanoparticles production process were evaluated obtaining nanoparticles with diameter below 250 nm and monomodal size distribution. Our system showed a sustained release profile in vitro. TMX‐PLA nanoparticles stability was performed in 15 days and demonstrated unsatisfactory stability due to zeta potential near zero. The TMX‐PLA nanoparticles have suitable physical, chemical and morphological characteristics, dealing for future tests delivery system for TMX as an alternative cancer therapy. Financial support: CNPq, CAPES, FAPDF, FINATEC, DPP‐UnB