Premium
Screening for obesity genotypes from a set of established T2D associated SNPs in a Saudi population
Author(s) -
AlDaghri Nasser,
Albagha Omar,
Alkharfy Khalid,
Alokail Majed,
AlAttas Omar,
Krishnaswamy Soundararajan
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.562.2
Subject(s) - single nucleotide polymorphism , type 2 diabetes , population , obesity , medicine , genotype , allele , snp , genetic association , allele frequency , genetics , biology , diabetes mellitus , endocrinology , gene , environmental health
Objective To explore for any positive association between 36 type 2 diabetes (T2D) associated single nucleotide polymorphisms (SNP) and BMI in a population of Saudi subjects. Methods Study consisted of 72 obese and 78 control Saudi subjects. DNA samples from obese and controls subjects were genotyped for 36 T2D linked SNPs using the KASPar method. The mean BMIs corresponding to each of the individual genotypes were compared. Results Four of the 36 T2D related SNPs, rs10923931, rs6795735, rs11642841 and rs4430796, located in or near NOTCH2, ADAMTS9, FTO and HNF1B genes, respectively, were found to be associated with BMI even after adjusting the data for age. The allelic variants rs6795735‐C and rs4430796‐A showed significant association with BMI in both males and females even after adjusting the data for age. However, rs10923931‐T allele was associated to age adjusted BMI data only in females. Some of the 36 SNP variants were found to be significantly associated with obesity related disease markers like systolic and diastolic blood pressure, cholesterol, triglyceride and fasting blood glucose levels but not with BMI. Conclusion We identified positive association between allelic variants of 4 of the 36 T2D related SNPs and BMI in a Saudi population and the significance of which persisted even after adjusting the data for sex and age.