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Structure‐functional study of proteins that regulate cell proliferation and differentiation
Author(s) -
Zhu Guang,
Zhou Bo
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.541.5
Subject(s) - cell cycle , regulator , homeobox , transcription factor , microbiology and biotechnology , dna replication factor cdt1 , cell growth , hox gene , biology , histone , phd finger , chemistry , cell , gene , genetics , control of chromosome duplication , zinc finger
Organ development requires precise regulation of both the total number and the different types of cells. It has been shown that these two processes are linked based on mutual regulation between the cell cycle‐regulator Geminin and homeodomain ‐containing transcription factors Hox. To understand the respective molecular mechanism, we conducted structure‐functional study of Cdt1, Geminin, Mcm6 and Hox proteins by NMR and carried out relevant biochemical studies to delineate the structural basis of this regulation (Liu et al (2012) NAR 40, 3208; Zhou et al (2012) PNAS 109, 8931). We also studied histone H4–K20 mono‐methyltransferase, SET8 and its roles in cell‐cycle (Yin et al (2008) Cell Cycle 7,1423). Our results indicate that SET8 is a new cell‐cycle regulator. These works are supported from Research Grants Council of Hong Kong (RGC664109, AoE/M‐06/08, RGC663911, TUYF).