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The Role of Nitric Oxide in Cardiopulmonary Endurance
Author(s) -
Adar Tony,
Baral Sumit,
Márquez Samuel
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.528.8
Subject(s) - nitric oxide , medicine , respiratory tract , vasodilation , vo2 max , inhalation , endurance training , respiratory system , ex vivo , anesthesia , heart rate , chemistry , blood pressure , biochemistry , in vitro
Nitric Oxide (NO) has been intensely investigated in various physiological as well as pathophysiological processes in humans but has received its greatest attention for its vasodilator properties. Since the nose and paranasal sinuses have been implicated as the sole producers of NO in the upper respiratory system, NO may be regarded as an aerocrine hormone produced in the nasal complex and transported to a distal site of action with every inhalation by enhancing pulmonary oxygen uptake via local vasodilation, thus facilitating athletic endurance. Our study examines fractional NO concentration (FeNO) response in expired air during exercise (Ex). A strict three step Ex protocol was followed in which FeNO measurements were obtained in 18 healthy human volunteers prior to Ex (rest stage (RS)), during a strenuous 200 w ergometer cycle and 5 minutes into the recovery period. FeNO measurements were performed according to ERS/ATS recommendations with an electrochemical sensor (Niox Mino Aerocrine Stockholm, Sweden). Results showed an overall decrease in average FeNO levels from resting stage to endurance phase of Ex (16.4 to 12.6 ppb p< .005) with levels increasing towards the original RS value 5 minutes into the recovery phase (12.6 to 14.1 ppb p< .005). Further investigation may shed light as to the exact mechanism of NO recruitment by the lower respiratory tract in maximizing cardiopulmonary endurance. Grant Funding Source : SUNY Downstate Alumni Association