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Natural infection of human adenovirus 36 in rhesus monkeys is associated with gain in body fat, yet, reduction in fasting glucose
Author(s) -
Dhurandhar Nikhil V,
Dhurandhar Emily J,
Ingram Donald K,
Cabo Rafa,
Mattison Julie A
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.48.2
Subject(s) - glycemic , endocrinology , medicine , obesity , physiology , diabetes mellitus
Experimental infection of Ad36 increases adiposity, yet improves glycemic control in rodents. In humans, natural Ad36 infection is temporally associated with gain in adiposity and better glycemic control. We determined associations of natural Ad36 infection with changes in adiposity and glycemic control in rhesus monkeys. Monkeys randomized 1y earlier to receive a diet of high fat and sucrose (HFS, N=10) or HFS+resveratrol (RES, N=10), were screened for neutralizing antibodies to Ad36. Ad36‐seropositive (POS; N=5 HFS; 5 RES) and seronegatives (NEG) were compared cross‐sectionally and after 1y follow‐up. In pooled HFS and RES groups, cross‐sectionally, NEG and POS groups did not differ in age, body fat, or fasting glucose (p>;0.9). However, 1y later, fat gain was 510g vs 1245g and reductions in fasting glucose were −3 and −10mg/dL for NEG vs POS, respectively. Gain in body fat and drop in fasting glucose after 1y follow‐up, were significant for POS (p<0.003), but not for NEG. When analyzed separately by diet and seropositivity, only the RES treated POS group showed significant reductions in fasting glucose during 1y follow up (p=0.007). In summary, Ad36 infection is linked with changes in adiposity and glycemic control. Considering effect of resveratrol on reduction in fasting glucose was augmented by Ad36 infection, the interaction may be further evaluated, particularly when studying metabolic interventions.