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Bone protective effects of dried plum is through increasing osteoprotegerin and suppressing sclerostin levels
Author(s) -
Hooshmand Shirin,
Brisco Jayme,
Elam Marcus,
Chai Sheau C,
Arjmandi Bahram H.
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.371.2
Subject(s) - sclerostin , osteoprotegerin , rankl , medicine , endocrinology , bone resorption , bone mineral , osteoporosis , bone remodeling , receptor , chemistry , activator (genetics) , biochemistry , signal transduction , wnt signaling pathway
Although several studies have confirmed the bone protective properties of dried plum, its exact mechanisms of action remain unclear. Recent research has shown that osteocytes may control bone formation via production of sclerostin and bone resorption via the receptor activator of nuclear factor kappa‐B ligand (RANKL) and its inhibitor osteoprotegerin (OPG). To investigate the mechanism of action of dried plum in reversing bone loss, we measured serum sclerostin and OPG levels in osteopenic postmenopausal women (n=160). Participants were randomly assigned to either the treatment group of 100g/day dried plum or a comparative control for one year. All participants received 500 mg Ca/400 IU vitamin D daily. Bone mineral density of lumbar spine, forearm, hip, and whole body were assessed at baseline and at the end of the study using DXA. Blood samples were collected at baseline and 12 months to assess bone biomarkers. Dried plum significantly increased BMD of ulna and spine in comparison to the control group. In comparison with corresponding baseline values, dried plum decreased serum sclerostin levels by −1.2% vs. +3.8% in the control group and increased OPG levels by +4.62% vs. −2.15% in controls. Hence, these preliminary data indicate that the positive effects of dried plum on bone are in part due to inhibition of sclerostin and promotion of OPG.