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Effect of pistachios on lipids, lipoproteins, glucose metabolism, and insulin sensitivity in type 2 diabetes
Author(s) -
Sauder Katherine A,
McCrea Cindy E,
KrisEtherton Penny M,
Ulbrecht Jan S,
West Sheila G
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.368.4
Subject(s) - dyslipidemia , medicine , type 2 diabetes , glycated hemoglobin , glycemic , endocrinology , diabetes mellitus , crossover study , insulin , insulin sensitivity , lipid profile , carbohydrate metabolism , cholesterol , lipid metabolism , insulin resistance , placebo , alternative medicine , pathology
Controlling blood sugar and dyslipidemia in diabetes is important for reducing cardiovascular morbidity and mortality. This study compared the effect of two diets on lipids, lipoproteins, glucose metabolism, and insulin sensitivity. We enrolled 28 adults with type 2 diabetes in a randomized, crossover, controlled‐feeding study with 4wk diet periods. After a 2 wk run‐in on a typical Western diet, participants consumed a low fat control diet and an isocaloric moderate fat pistachio diet, in which pistachios contributed 20% of energy. At the end of each diet period, we assessed lipid and glycemic parameters while fasted and during a standard 75g oral glucose tolerance test. Compared to baseline, the control diet increased fasting triglycerides (140 vs 164 mg/dl) and the total:HDL cholesterol ratio (4.0 vs. 4.3), but these parameters were unaffected by the pistachio diet (142 mg/dl and 4.0, respectively); this differential response was statistically significant (all p<0.01). Glucose and insulin levels were not affected by the diets; however, glycated hemoglobin was reduced from baseline following both diets, with significantly larger reductions following the pistachio diet than the control diet (6.19% vs 6.02% and 6.07%, respectively, p=0.03). Taken together with other recent studies, these results provide evidence that pistachio consumption can benefit insulin sensitivity in adults with type 2 diabetes. Grant Funding Source : American Pistachio Growers