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Influence of long‐term exercise training followed by a diet/exercise weight‐loss intervention on body composition and metabolic variables in subjects with pre‐diabetes
Author(s) -
Starr Kathryn N,
Granville Esther O,
Ocampo Christine I,
Slentz Cris A,
Bateman Lori A,
Willis Leslie H,
Rose Sarah B,
Kraus William E,
Bales Connie W
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.368.2
Subject(s) - medicine , waist , aerobic exercise , endocrinology , weight loss , diabetes mellitus , zoology , obesity , biology
Lifestyle measures such as diet and exercise are strongly encouraged to reduce diabetes risk; however, studies of longer than 6 month's duration are rare and strategies for long‐term adherence remain elusive. The goal of this study was to examine the health impact of a 12‐month lifestyle intervention in women and men (n =21; mean age = 61.2 yrs) who had pre‐diabetes at baseline, defined as a fasting blood glucose (FBG) of 95–124 mg/dl on 2 occasions. Body mass (BM) and composition, namely fat (FM in kg and %) and fat‐free (FFM in kg and %) mass by BodPod, waist circumference (WC), hip circumference (HC) and plasma levels of total (TC) and HDL‐cholesterol (HDL‐C), triglycerides (TG) and FBG were assessed at baseline (B), after 6 months of aerobic exercise training (6‐ET), and after an additional 6 months of combined diet/aerobic exercise (12‐ET). Compared to B, values at 6‐ET were lower (p<0.001) for BM, FM %, FM kg, WC, and HC, and higher for FFM % and HDL‐C. At 12‐ET compared to 6‐ET, there were significant improvements in BM (p<0.0001), FM % (p<0.05), FFM kg (p<0.01), FFM % (p<0.05), WC (p<0.0001), HC (p<0.001), TG (p<0.01), and HDL‐C (p<0.01). FBG, LDL‐C, and TC were essentially unchanged during the trial. Our findings show that adding a weight loss and exercise treatment after 6 months of aerobic exercise confers additive improvements in body mass and composition and in TG and HDL‐C. Supported by NIDDK R01‐ DK081559 and NIA AG000029.