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Leptin and lipids serum concentration on early pregnancy and 2nd and 3rd trimester blood pressure levels: A prospective cohort study in Rio de Janeiro, Brazil
Author(s) -
Kac Gilberto,
Farias Dayana Rodrigues,
FrancoSena Ana Beatriz,
Jesus Thatiana,
Santos Vaz Juliana
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.366.2
Subject(s) - medicine , leptin , pregnancy , blood pressure , lipid profile , body mass index , prospective cohort study , endocrinology , blood lipids , obstetrics , cholesterol , obesity , biology , genetics
Little is known about lipid profile during pregnancy and 2nd and 3rd trimester blood pressure levels (BPL). Objective To test the association of lipid profile early in pregnancy and the 2nd and 3th trimester BPL. Methods Prospective cohort of 226 pregnant women followed at 8–13th, 22–24th and 30–34th weeks. The main covariates were total cholesterol, triglycerides, high‐density lipoprotein (HDL‐c), low‐density lipoprotein (LDL‐c) and leptin. The outcome was diastolic blood pressure (DBP) and systolic blood pressure (SBP) variation from the 2nd to the 3rd trimester. Analyses were performed with linear mixed effect models, controlling by obstetric and socioeconomic variables. Results Time elapsed between the 2nd and 3rd trimester and pre‐pregnancy body mass index were associated with DBP and SBP. Triglycerides (SBP: β=0.0638, p=0.010), total cholesterol (SBP: β=0.0533, p=0.017; DBP: β=0.0319, p=0.077) and LDL‐c (SBP: β=0.0756, p=0.010; DBP: β=0.0475, p=0.029) were also associated with DBP or SBP. First trimester leptin levels were associated with SBP (β=0.1311, p=0.001) and DBP (β=0.102, p<0.001). Conclusion Our results showed that leptin and lipid profile early in pregnancy might play a role on the BPL change from the 2nd to the 3rd trimester.