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Effects of exercise on fasting triglyceride‐rich lipoproteins from hepatic and intestinal origin
Author(s) -
Egli Léonie,
Lecoultre Virgile,
Theytaz Fanny,
Schneiter Philippe,
Tappy Luc
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.361.2
Subject(s) - lipogenesis , medicine , endocrinology , triglyceride , fructose , dyslipidemia , chemistry , carbohydrate , lipoprotein , cholesterol , biochemistry , lipid metabolism , diabetes mellitus
A high fructose intake increases fasting triglyceride‐rich lipoproteins (TRL). This is due, at least in part, to a stimulation of hepatic de novo lipogenesis and TRL secretion. Unlike in rodents, the role of the enterocytes in fructose‐induced de novo lipogenesis and TRL secretion remains not established in humans. We therefore assessed the effects of a high fructose diet on fasting blood triglyceride (TG) and apob48 concentrations as well as TRL (sf 20–400) TG content. Since exercise may prevent carbohydrate‐induced dyslipidemia, we measured the effects of an isocaloric, high fructose diet both with and without daily exercise in 8 healthy male subjects. A fasting blood sample was obtained after 4 days on a low‐fructose diet without exercise (control, C), a 30% fructose diet and no exercise (HFr), and a 30% fructose diet with aerobic exercise (HFrEx). HFr increased apoB48 from 4.55 ± 0.73 to 8.13 ± 0.94 μg/mL, total TG from 0.65 ± 0.07 to 0.94 ± 0.14 and TRL‐TG from 0.43 ± 0.07 to 0.69 ± 0.13 mmol/L (all p<0.05 vs C). HFrEx completely prevented the effects of HFr and restored fasting apoB48 concentrations (5.29 ± 0.85), TG (0.63 ± 0.06), TRL‐TG (0.37 ± 0.06), to values comparable to those observed after C (all p=NS vs C). Our data suggest that the gut contributes to fructose‐induced de novo lipogenesis, and can adapt to short‐term changes in the diet and to exercise. Swiss National Science Foundation supported this work.