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Fat‐soluble vitamin status in response to non‐surgical weight loss in overweight post‐menopausal women
Author(s) -
Prokopy Max,
Booth Sarah L,
Saltzman Edward,
Yeum KyungJin,
Nicklas Barbara,
Shea M Kyla
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.360.5
Subject(s) - weight loss , overweight , medicine , obesity , endocrinology , vitamin , adipose tissue , fat soluble vitamin , vitamin d and neurology , zoology , biology
Obesity is associated with an increased risk of fat soluble vitamin (FSV) deficiencies. The effect of dietary weight loss on FSV status is uncertain. We measured plasma concentrations of carotenoids, α‐tocopherol, retinol, phylloquinone, and 25‐hydroxyvitamin D (25(OH)D) in 112 overweight post‐menopausal women (mean(SD) BMI=33.1(3.7) kg/m 2 ) who participated in a 20‐week hypocaloric weight‐loss intervention. Mean(SD) weight loss was −12.1(4.5) kg. All women received 200 IU/day vitamin D 3 . Except for 25(OH)D, the same FSVs were measured in adipose tissue. Using repeated measures ANOVA adjusted for the respective baseline FSV concentration and potential confounders, the following plasma FSVs increased significantly postintervention (all p<0.01): 25(OH)D (median increase 8.0 to 9.0 nmol/l), α‐carotene (0.09 to 0.13 μmol/l), and cryptoxanthin (0.11 to 0.13 μmol/l). The other FSV concentrations in plasma and adipose tissue generally increased but changes were not statistically significant (all p>;0.05). Modest weight loss achieved through caloric restriction was associated with modest increases in some FSV concentrations, although the clinical relevance is uncertain. Grant Funding Source : NIH (grant R01‐AG/DK20583), Wake Forest University Claude D Pepper Older Americans Independence Center (P30‐AG21332), and Wake Forest University General Clinical Research Center (M01‐RR07122).