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Effects of iron deficiency on the production of proinflammatory cytokines in 8 to 12 year‐old children
Author(s) -
GarcíaMiranda Luis Armando,
Estrada José Antonio,
ParedesCervantes Vladimir,
Contreras Irazú
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.357.6
Subject(s) - proinflammatory cytokine , iron deficiency , medicine , anemia , erythropoiesis , overweight , immunology , endocrinology , physiology , obesity , inflammation
Iron is an essential nutrient for many metabolic processes, which include erythropoiesis, oxidative metabolism and the immune response. Iron deficiency (ID) is considered a worldwide public health problem. The objective of this study was to determine the prevalence of ID and its effects on the production of proinflammatory cytokines (TNF‐α and INF‐γ) in 8 to 12 year‐old children from a community in the State of Mexico. Blood samples were obtained from 100 children; weight and height were also measured. Serum was used to determine iron concentrations by spectrophotometry, as well as TNF‐α and INF‐γ production by ELISA. In addition, a complete blood count was performed. ID was considered with values ≤ 60 μg/dL. We observed a high prevalence (>;50%) of overweight children; ID was determined in 19% of children. The percentage of children with iron deficiency anemia (Hb ≤ 11 g/dl) was 5%. Blood differential showed a decreased frequency of lymphocytes and increased frequency of neutrophils in children with ID, although the total number of leucocytes was unaltered. INF‐γ production was reduced 16% in the ID group compared to the control group. We observed no difference in TNF‐α production between groups.