Lycopene up‐regulates mRNA expressions of SIRT and adiponectin and down‐regulates PPARγ and IL‐6 in adipose tissue of hypercaloric diet‐fed rats | Zendy

Luvizotto Renata AM | Zendy; Nascimento Andre F | Zendy; Miranda Natália CM | Zendy; Pierine Damiana T | Zendy; Imaizumi Erika | Zendy; Presti Paula T | Zendy; Correa Camila R | Zendy; Yeum KyungJin | Zendy; Wang XiangDong | Zendy; Ferreira Ana Lucia A | Zendy

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Lycopene up‐regulates mRNA expressions of SIRT and adiponectin and down‐regulates PPARγ and IL‐6 in adipose tissue of hypercaloric diet‐fed rats

Author(s) -

Luvizotto Renata AM,

Nascimento Andre F,

Miranda Natália CM,

Pierine Damiana T,

Imaizumi Erika,

Presti Paula T,

Correa Camila R,

Yeum KyungJin,

Wang XiangDong,

Ferreira Ana Lucia A

Publication year - 2013

Publication title -

the faseb journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.709

H-Index - 277

eISSN - 1530-6860

pISSN - 0892-6638

DOI - 10.1096/fasebj.27.1_supplement.356.3

Subject(s) - lycopene , adipose tissue , adiponectin , medicine , endocrinology , foxo1 , corn oil , inflammation , obesity , placebo , leptin , adipokine , chemistry , insulin resistance , gene , biochemistry , carotenoid , pathology , alternative medicine , transcription factor

Objective To evaluate the effect of lycopene supplementation on inflammation in adipose tissue of obese rats. Methods Male Wistar rats were first fed control diet (C, n=6) or hypercaloric diet (HD, n=12) for 6 wks. Afterwards, the HD rats were randomized into two groups: HD [placebo (corn oil)] or HD+L [lycopene (10 mg/Kg BW/day in corn oil)] by gavage for 6 wks. Plasma lycopene concentration was analyzed by a HPLC system. The mRNA expressions of SIRT1, FoxO1, adiponectin, PPARγ, MCP‐1 and IL‐6 in adipose tissue were determined by real time PCR. Results Lycopene was detected in plasma (24 nmol/L) from HD+L group only. The mRNA expressions of adiponectin, SIRT1 and FoxO1 decreased significantly but PPARγ, MCP‐1 and IL‐6 increased significantly in adipose tissue from HD group, as compared with those of C group. Although there was no difference in adiposity index between the HD and HD+L group, lycopene supplementation restored the reduced expressions of SIRT1 and FoxO1 to the levels of the C group and inhibited the up‐regulations of PPARγ, MCP‐1 and IL‐6 mRNA expressions in the HD+L group. Conclusion Lycopene modulates several key inflammatory genes in adipose tissue indicating its potential protective effect against obesity‐related inflammation. Financial Support: FAPESP (2010/06100–9; 2010/19746–4; 2011/22786–0)

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