Premium
A surveillance of micronutrient status in bariatric surgery patients
Author(s) -
Wright Breanne Natasha,
Myers CathyAnn Mary,
Van Meter Marnie A.,
Mattar Samer G.,
GletsuMiller Nana
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.349.4
Subject(s) - ceruloplasmin , micronutrient , copper deficiency , medicine , malnutrition , anemia , micronutrient deficiency , ferritin , gastroenterology , iron deficiency , hemoglobin , copper , zinc , surgery , chemistry , pathology , organic chemistry
Roux‐en‐y gastric bypass surgery (RYGB) is effective for weight loss, but may promote malnutrition. To confirm our earlier findings of copper deficiency and further examine associated malnutrition following RYGB, we recruited 46 patients and determined blood concentrations of copper (Cu), hemoglobin, ferritin, folate, zinc (Zn), C‐reactive protein (hsCRP), and vitamins B 1 , B 6 , and B 12. Plasma ceruloplasmin activity (Cp) was assayed using the oxidase method. Statistical analysis included mean ± S.E., Pearson correlations and p‐value < 0.05. Subjects were age 49 ± 1, 5.2 ± 0.7 years post RYGB, and predominantly female (91%) and Caucasian (80%). The prevalence (%) of nutrient deficiencies were: copper (Cu= 2, Cp= 13); anemia= 17; iron= 17; Zn= 22, B 1 = 4, B 6 = 6; B 12 = 4; and folate= 0, despite high self‐reported compliance in micronutrient supplementation (89%). Elevated hsCRP concentrations were observed (37%). Correlations were found between hsCRP and Cu (r = 0.33), Cp (r = 0.35) and Zn (r = −0.29). The biomarker Cp suggested a 13% prevalence of copper deficiency, similar to previous reports. The high prevalence of elevated hsCRP, and associations with copper and Zn, suggests that inflammation may mask copper deficiency and overestimate Zn deficiency. This study highlights the need for more sensitive measures of nutrition status in order to optimize post‐surgery health. Support by International Copper Association. Grant Funding Source : International Copper Association